Speaker Profile
Prof. Ren-Wang Peng, Ph.D.—Associate Professor & Principal Investigator, University Hospital Bern (Inselspital) and Faculty of Medicine, University of Bern—has spent two decades decoding how solid tumours evade therapy. Trained at the Chinese Academy of Sciences, Max Planck Institute, and ETH Zürich, he leads an internationally collaborative lab focused on lung cancer, mesothelioma, cancer stem cells, and therapeutic resistance. His portfolio spans 100 + high-impact publications.
Talk Title
“Lactate dehydrogenase B noncanonically promotes ferroptosis defense in KRAS-driven lung cancer”
Why This Matters
Ferroptosis—an oxidative, iron-dependent form of cell death—should be a potent weapon against cancer, yet many tumours have learned to disarm it. Prof. Peng’s latest work reveals that the metabolic enzyme LDHB, not its better-known sibling LDHA, is a hidden shield that protects KRAS-mutant lung tumours from ferroptosis. Silencing LDHB crashes glutathione reserves, unleashing mitochondrial ROS and triggering a KRAS-specific synthetic lethality. The result: a new therapeutic window that pairs GSH-targeted agents with KRAS context for maximum tumour kill.
Key Takeaways for Attendees
• Distinguish LDHB from LDHA in ferroptosis defense
• Understand how STAT1-mediated repression of SLC7A11 dismantles glutathione metabolism
• Explore combination-therapy concepts that exploit ferroptosis susceptibility in KRAS-mutant lung cancer
• Gain translational insights ready for drug-development pipelines
Event Snapshot
• Conference: International Conference on Cancer Science & Research (Cancer 2025)
• Dates: 17 – 19 November 2025
• Format: Hybrid — Singapore & Global Online
• Theme: Oncology Nexus – Innovate, Collaborate, Conquer Cancer
Register & Participate
Secure your onsite seat or virtual pass to engage directly with Prof. Peng during live Q&A, network with peers across five precision-oncology tracks, and publish your research in proceedings.
👉 Register now: https://cancer.miconferences.com/register
Contact
cancer@mathewsconference.com | +1 (312) 462-4448 | WhatsApp +1 (424) 377 0967
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