At the upcoming Cancer Conference 2025, Dr. Minoo Shahidi from the Iran University of Medical Sciences will present her latest findings on the role of Resveratrol (RSV) in reducing the formation of extracellular traps (ETs) in acute promyelocytic leukemia (NB4) cells. ETosis and NETosis, which drive cancer progression, metastasis, and thrombosis, are increasingly seen as potential therapeutic targets. Dr. Shahidi’s study focuses on how Resveratrol, a naturally occurring antioxidant, can help regulate these processes and improve patient outcomes.
The
research demonstrates that RSV treatment significantly decreases PAD4
gene expression and lowers TNF-Ξ± cytokine release
in NB4 cells, both of which are critical in ETosis. Using advanced tools such
as fluorescence microscopy, flow cytometry, PCR, and ELISA, her team confirmed
RSV’s ability to suppress ETosis. These findings suggest that Resveratrol could
potentially reduce bleeding risks and treatment failure in Acute
Promyelocytic Leukemia (APL) patients by limiting
ETosis-driven complications.
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Key Highlights from the Presentation
·
ETosis and NETosis play a major role in cancer spread and
thrombosis.
·
Resveratrol (RSV) acts as a natural
inhibitor of ETosis in NB4 cell lines.
·
RSV treatment led to a reduction in PAD4 expression
and TNF-Ξ± cytokine levels.
·
Advanced research methods validated RSV’s therapeutic potential.
·
The study points to new pathways for improving
APL treatment outcomes.
π©⚕️ About Dr.
Minoo Shahidi
Dr.
Shahidi is a distinguished Immunohematologist specializing in cancer,
angiogenesis, and NETosis. She earned her PhD from Surrey
University, UK, and currently serves as an Associate
Professor at the Department of Hematology and Blood Banking, Iran
University of Medical Sciences. Her extensive research has contributed
significantly to the understanding of hematologic malignancies and inflammatory
processes.
π Event Details
Event Name: International Conference on Cancer Science and Research
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Venue:
Village Hotel Changi, 1 Netheravon Rd, Singapore 508502 & Online
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Website:
cancer.miconferences.com
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Abstract
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Email: cancer@mathewsconference.com
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Phone: +1 (312) 462-4448 | WhatsApp: +1 (424) 377 0967
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