A remarkable new study by Dr. Viviana C. Blank from the University of Buenos Aires, Argentina, shines light on a powerful drug combination that could change the way we treat breast cancer. Her research uncovers how two compounds — 2´nitroflavone (2NF) and safingol — work together to attack cancer cells through multiple molecular pathways.
Dr.
Blank will be presenting her latest findings at the upcoming International
Conference on Cancer Science and Research, happening November
17–19, 2025, in Singapore and Online.
🔍 What Makes This Research Stand Out
The
study focuses on disrupting the SPHK1/sphingosine-1-phosphate (S1P) signaling axis
— a crucial mechanism that helps cancer cells survive and multiply. By
combining 2NF,
a flavonoid with known anticancer potential, and safingol,
a sphingosine kinase inhibitor, Dr. Blank and her team observed remarkable synergistic
antitumor effects in breast cancer models.
⚗️ Key Discoveries from the Study
·
🧬 Molecular
Targeting: 2NF directly interacts with SPHK1 near the Ser225 site,
preventing phosphorylation and blocking its translocation to the cell membrane.
·
💥 Enhanced
Tumor Cell Death: The 2NF and safingol combination
significantly reduces
cancer cell proliferation and promotes apoptosis.
·
🔬 MAPK
Activation: The dual treatment triggers key signaling pathways
— p38,
JNK, and ERK MAPKs — which play a central role in cell stress
and death.
·
⚙️ ER Stress Induction:
The combination boosts endoplasmic reticulum (ER) stress responses,
further contributing to tumor cell destruction.
·
🧪 Therapeutic
Implication: Findings suggest a multi-targeted therapeutic
approach could be more effective than single-drug treatments in
breast cancer management.
👩🔬 About Dr. Viviana C. Blank
Dr.
Blank is a biochemist
and senior researcher at the University of Buenos Aires
and a member
of CONICET. She holds a Ph.D. in Biological Chemistry and has dedicated
her career to exploring flavonoids and synthetic molecules with anticancer
activity.
Her passion lies in uncovering molecular mechanisms of tumor inhibition and
developing potential therapeutic strategies that can improve patient outcomes.
🧭 Conference Information
📅 Dates:
November 17–19, 2025
📍 Venue:
Singapore & Online (Hybrid Event)
🎓 Event:
International
Conference on Cancer Science and Research
🌐 Website:
https://cancer.miconferences.com/
📝 Register
Here: https://cancer.miconferences.com/register
💬 Submit
Abstract: https://cancer.miconferences.com/abstract-submission
📧 Email:
cancer@mathewsconference.com
📞 Phone:
+1 (312) 462-4448
📱 WhatsApp:
+1 (424) 377 0967
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Updates: @CancerWorldConf
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