👩⚕️ Presented by: Dr. Nira Ben-Jonathan, University of Cincinnati, USA
📣 Presentation Type: Oral
(In-Person)
Title: Suppression
of breast cancer by small molecules that block the prolactin receptor
🔍
Revolutionizing Breast Cancer Treatment
Breast cancer continues to challenge researchers worldwide, but new
insights are paving the way for innovative treatments. Dr. Nira Ben-Jonathan,
an eminent cancer biologist from the University of Cincinnati, presents an
exciting pre-clinical breakthrough — small molecules capable of blocking the prolactin receptor (PRLR) and halting
tumor growth.
💡 Key
Findings & Scientific Insights
- 🔸 Discovery
of Novel Inhibitors: Two small molecule inhibitors, SMI-1 and SMI-6, were identified through
high-throughput screening of 51,000 compounds.
- 🔸 Precise
Mechanism: Both molecules effectively bind to the prolactin receptor,
disrupting its role in tumor cell proliferation and invasion.
- 🔸 Powerful
Selectivity: SMI-6
stands out for targeting malignant breast cancer cells while sparing
normal, healthy cells.
- 🔸 Preclinical
Success: In animal models, SMI-6
dramatically reduced breast cancer tumor growth with no visible toxicity.
- 🔸 Therapeutic
Advantages: Oral deliverability, potential brain penetration (for
metastases), and ease of optimization make SMI-6 a strong candidate for future cancer therapies.
🌿 Why This
Study Matters
Prolactin, a hormone produced in both the pituitary and other tissues,
has been known to promote cancer growth. By blocking its receptor, Dr.
Ben-Jonathan’s team introduces a new strategy to prevent tumor progression and enhance treatment selectivity — marking a significant step
toward targeted, non-toxic cancer
therapies.
👩🔬 About Dr. Nira Ben-Jonathan
A highly respected leader in cancer biology, Dr. Ben-Jonathan’s career
is decorated with achievements:
- Authored over 180 scientific papers and 12 textbook
chapters.
- Fellow of the AAAS and Royal
Society of Medicine.
- Recipient of the NIH Research Career Development Award, Rieveschl
Award, and Merker Lectureship in Translational Endocrinology.
- Served on multiple NIH, DOD, and Komen Foundation committees,
and chaired five NIH Study Sections.
Her research continues to shape the understanding of hormonal regulation
in cancer biology and inspire future generations of scientists.
🌏 Join the
Global Cancer Science Community
Be part of the International
Conference on Cancer Science and Research (ICCSR 2025) — a hybrid event
uniting global experts to discuss breakthroughs in cancer prevention,
diagnosis, and therapy.
🎓 Event: International Conference on Cancer Science and Research
📅 November 17–19, 2025 | 📍 Singapore
& Online
🔗 Visit Official
Website
👉 Register Now:
https://cancer.miconferences.com/register
🧬 Submit Your
Abstract: https://cancer.miconferences.com/abstract-submission
📧 Email:
cancer@mathewsconference.com | 📞 +1
(312) 462-4448
💬 WhatsApp:
+1 (424) 377 0967
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