GPER-driven Crosstalk in Breast Cancer: Bridging Drug Resistance and Tumor Microenvironment Remodelling

We are honored to announce that Dr. Tenghua Yu, Associate Chief Physician and Deputy Director of the Breast Surgery Department at Jiangxi Cancer Hospital & Institute, China, will be delivering an Oral Virtual Presentation at the International Conference on Cancer Science and Research, scheduled for November 17–19, 2025, at Village Hotel Changi, Singapore.

Presentation Overview

Triple-negative breast cancer (TNBC) remains one of the most aggressive and challenging forms of breast cancer, marked by poor prognosis and limited treatment options. Dr. Yu’s research sheds new light on the role of G protein-coupled estrogen receptor (GPER) in regulating the tumor microenvironment, particularly its interaction with cancer-associated fibroblasts (CAFs).

His study reveals how estrogen-activated GPER in CAFs stimulates glutamine production through the upregulation of key metabolic enzymes (GLUL and LDHB). This glutamine is then secreted and absorbed by TNBC cells, fueling their growth, motility, and resistance to chemotherapy. By elucidating the GPER/cAMP/PKA/CREB signaling pathway and its impact on metabolic coupling, Dr. Yu identifies GPER as a critical mediator of tumor progression.

The findings emphasize that targeting the estrogen/GPER/glutamine axis could offer promising therapeutic strategies to overcome resistance and suppress TNBC progression. This work highlights the growing importance of metabolic interventions in cancer treatment.

About Dr. Tenghua Yu

Dr. Yu is a dedicated clinician and researcher specializing in breast cancer treatment and tumor microenvironment studies. He earned his PhD from Chongqing Medical University (2013–2016) and furthered his research training at the University of Chicago Medical Center, USA (2024–2025). With more than 30 peer-reviewed publications in esteemed journals such as Oncogene, Clinical and Translational Medicine, and Molecular Cell Endocrinology, Dr. Yu continues to make significant contributions to the field of oncology.

Conference Details

📅 Dates: November 17–19, 2025
📍 Venue: Village Hotel Changi, 1 Netheravon Rd, Singapore 508502
🌐 Website: https://cancer.miconferences.com/
📧 Email: cancer@mathewsconference.com
📞 Phone: +1 (312) 462-4448
💬 WhatsApp: +1 (424) 377 0967

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Extracellular vesicle pathways as regulators of tumor-vascular interactions in glioblastoma

🧠 Virtual Presentation Spotlight – Cancer Conference 2025

📅 November 17–19, 2025 | 📍 Village Hotel Changi, Singapore & Online
🌐 Event Website

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We are delighted to welcome Prof. Janusz Rak, MD, PhD, McGill University, Canada, as a distinguished Oral Virtual Presenter at the Cancer Conference 2025. Prof. Rak is a world-leading expert in pediatric hematology/oncology, renowned for his pioneering research into how cancer cells communicate with their environment via extracellular vesicles (EVs).

Presentation Title:
Extracellular vesicle pathways as regulators of tumor-vascular interactionsin glioblastoma

Glioblastoma (GBM) remains one of the most aggressive and lethal brain tumors, resisting conventional therapies despite decades of study. Prof. Rak’s groundbreaking work sheds new light on the critical role of extracellular vesicles in orchestrating communication between glioma stem cells (GSCs) and the vascular system—driving processes like angiogenesis, vasectasia, and immune cell access to tumor tissue.

His team has uncovered that GSC subtypes secrete unique repertoires of EVs, influencing vascular growth patterns in GBM. Of particular interest is their discovery of a VEGF-independent blood vessel enlargement process—vasectasia—triggered by EV-mediated transfer of oncogenic EGFRvIII to endothelial cells, which resists standard angiogenesis inhibitors. Moreover, endothelial-derived EVs can reprogram proneural GSCs into more invasive, therapy-resistant mesenchymal phenotypes. These insights reveal new therapeutic possibilities, including combining vascular modulation with immunotherapy to improve treatment outcomes.

About the Speaker:
Prof. Janusz Rak is a Professor of Pediatrics and Jack Cole Chair in Pediatric Hematology/Oncology at McGill University. He directs the Centre for Applied Nanomedicine (CAN) and leads innovative projects on EV-based liquid biopsy approaches in pediatric cancer. He is also a Fellow of the Royal Society of Canada, recognized for his exceptional contributions to cancer biology.

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📞 Contact Us
📧 Email: cancer@mathewsconference.com
📱 WhatsApp: +1 (424) 377 0967
📞 Phone: +1 (312) 462-4448

#Glioblastoma #BrainCancerResearch #CancerConference #LiquidBiopsy #OncologyResearch #VirtualConference #MedicalResearch #Cancer2025

Keynote Speaker Announcement – International Conference on Cancer Science and Research 2025

We are thrilled to announce that Dr. Henrique Manuel dos Santos Faneca from the University of Coimbra (CNC-UC), Portugal, will join us as a Virtual Keynote Speaker at the upcoming International Conference on CancerScience and Research, scheduled for November 17-19, 2025, at Village Hotel Changi, Singapore, with an online participation option.

Presentation Title: Targeted gene and drug delivery nanosystems tohepatocellular carcinoma

Dr. Faneca’s pioneering work focuses on developing innovative nanosystems for the targeted delivery of drugs and genetic material to liver cancer cells. These systems are designed to maximize therapeutic benefits while reducing side effects, representing a promising advancement in the fight against HCC.

Join us for this insightful keynote and connect with experts in cancer research from around the world.

🔗 Register Today: https://cancer.miconferences.com/register
🌐 Visit Website: https://cancer.miconferences.com/

📧 cancer@mathewsconference.com | 📞 +1 (312) 462-4448 | 📱 WhatsApp: +1 (424) 377 0967

#CancerScience2025 #HCCResearch #Nanomedicine #GeneTherapy #CancerTreatment #MedicalConference