We are honored to announce that Dr. Tenghua Yu, Associate Chief Physician and Deputy Director of the Breast Surgery Department at Jiangxi Cancer Hospital & Institute, China, will be delivering an Oral Virtual Presentation at the International Conference on Cancer Science and Research, scheduled for November 17–19, 2025, at Village Hotel Changi, Singapore.
Presentation
Overview
Triple-negative
breast cancer (TNBC) remains one of the most aggressive and challenging forms
of breast cancer, marked by poor prognosis and limited treatment options. Dr.
Yu’s research sheds new light on the role of G protein-coupled estrogen
receptor (GPER) in regulating the tumor microenvironment,
particularly its interaction with cancer-associated fibroblasts (CAFs).
His
study reveals how estrogen-activated GPER in CAFs stimulates glutamine production
through the upregulation of key metabolic enzymes (GLUL and LDHB). This
glutamine is then secreted and absorbed by TNBC cells, fueling their growth,
motility, and resistance to chemotherapy. By elucidating the GPER/cAMP/PKA/CREB
signaling pathway and its impact on metabolic coupling, Dr. Yu
identifies GPER as a critical mediator of tumor progression.
The
findings emphasize that targeting the estrogen/GPER/glutamine axis could
offer promising therapeutic strategies to overcome resistance and suppress TNBC
progression. This work highlights the growing importance of metabolic
interventions in cancer treatment.
About
Dr. Tenghua Yu
Dr.
Yu is a dedicated clinician and researcher specializing in breast cancer
treatment and tumor microenvironment studies. He earned his PhD
from Chongqing
Medical University (2013–2016) and furthered his research
training at the University of Chicago Medical Center, USA (2024–2025).
With more than 30 peer-reviewed publications in esteemed journals
such as Oncogene,
Clinical and Translational Medicine, and Molecular
Cell Endocrinology, Dr. Yu continues to make significant
contributions to the field of oncology.
Conference
Details
📅 Dates:
November 17–19, 2025
📍 Venue:
Village Hotel Changi, 1 Netheravon Rd, Singapore 508502
🌐 Website:
https://cancer.miconferences.com/
📧 Email:
cancer@mathewsconference.com
📞 Phone:
+1 (312) 462-4448
💬 WhatsApp:
+1 (424) 377 0967
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