Featured Speaker: Dr. Alain Chapel, Institute of Radiological Protection and Nuclear Safety, France
Session Type: Oral Virtual Presentation
🌟 Why This Research Matters
Radiotherapy remains a cornerstone in cancer treatment, but nearly
5–10% of patients develop serious long-term side
effects, especially after pelvic radiation. These complications often lack standardized
treatment, making innovation in this area a pressing need. Dr. Alain Chapel and
his team have been exploring mesenchymal
stromal stem cell (MSC) therapy as a potential breakthrough
solution.
🔍 Key Insights from the Study
·
Clinical
Problem: Late adverse gastrointestinal and pelvic complications
post-radiotherapy can be life-threatening.
·
Preclinical
Evidence: Animal models demonstrated that systemic MSC injections
significantly alleviated radiation-induced damage.
·
Phase
I Clinical Trial Results:
o Patients
experienced reduction in diarrhea, pain,
hemorrhage, and inflammation.
o Fistulization
process was halted in one patient with remission lasting over 3 years.
o No
toxicity observed, supporting a favorable safety profile.
·
Ongoing
PRISME Trial (NCT02814864):
o Involves
12 patients across 6 radiotherapy centers.
o Each
patient receives three MSC injections
at weekly intervals.
o Primary
goal: measurable improvement on LENT SOMA
scale for rectal bleeding or hematuria.
o Secondary
goals: reduced need for pain medication, fewer digestive issues, and better
quality of life.
·
Future
Outlook: A Phase III clinical trial
is planned if current results confirm long-term efficacy.
👨🔬 About Dr. Alain Chapel
Dr. Alain Chapel, PhD, has dedicated more than 30 years to
advancing cell and gene therapy for radiation-induced
damage. His work bridges experimental models with real-world clinical
applications. He has collaborated on groundbreaking compassionate trials
demonstrating MSC therapy’s effectiveness in hematopoietic failure,
radiodermatitis, and radiotherapy overdoses. His extensive contributions also
include editorial roles in leading international journals and active
participation in global research societies.
📢 Join the Conference
Be part of this global platform where cutting-edge cancer research
meets clinical innovation.
Event: International Conference on
Cancer Science and Research
📍 Venue: Village Hotel Changi, Singapore
📅 Dates: November 17–19, 2025
🌐 Website: cancer.miconferences.com
✉️ Email:
cancer@mathewsconference.com
📞 Phone:
+1 (312) 462-4448 | WhatsApp:
+1 (424) 377 0967
👉 Register Now
| Submit Abstract
#CancerScience2025
#StemCellResearch #RadiotherapyComplications #CancerTreatment
#OncologyConference #MSCtherapy #CancerInnovation #CancerResearch