📅 Event Dates: November 17–19, 2025
📍 Venue: Village Hotel Changi, Singapore | 🌐 Hybrid
(In-Person & Virtual)
🎤 Speaker: Dr. Constantinos M. Mikelis, University of Patras, Greece
Title : The regulatory role of endothelial RhoA on tumor
microenvironment
🔬 Presentation Highlights
· The endothelial barrier
actively regulates tumor growth, dissemination, and metastasis.
·
Transendothelial
migration of tumor cells is a key
step in metastasis.
·
Research findings
show that endothelial RhoA
activation plays a decisive role
in this process.
·
Breast tumor cells
trigger endothelial RhoA via paracrine
signaling and cell-to-cell contact.
·
Blocking RhoA
genetically or pharmacologically reduces
tumor cell migration and metastasis
in human and murine tumor models.
·
These results
identify endothelial RhoA as a
universal therapeutic target for
anti-metastatic treatment of solid tumors.
👨🔬 About Dr. Constantinos M. Mikelis
·
Associate
Professor of Physiology at the University
of Patras, Greece.
·
Adjunct Associate
Professor at Texas Tech University
Health Sciences Center, USA.
·
PhD focused on
angiogenesis, University of Patras.
·
Postdoctoral
training at NIH, USA in vascular and cancer biology.
·
Research
expertise: Small GTPases, GPCRs,
angiogenesis, endothelial biology, and tumor microenvironment.
📢 About the Event – International Conference on Cancer
Science and Research 2025
This global event will gather leading
oncologists, researchers, clinicians, and industry experts to share cutting-edge advancements in cancer biology, therapy, and
clinical research.
·
🌍 Hybrid Mode: Attend in Singapore or join virtually.
·
📄 Abstract Submission: Click Here
·
📝 Registration: Click Here
·
🔗 Event Website
📧 Email: cancer@mathewsconference.com
📞 Phone: +1 (312) 462-4448
📲 WhatsApp: +1 (424) 377 0967
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