Presenter: Dr. Chia-Jung Li, Kaohsiung Veterans General Hospital, Taiwan
Presentation
Type: Poster (In-Person)
Title: Functional
Integration of the ATP Synthasome Drives Mitochondrial Efficiency in Breast
Carcinoma
🔍 Overview
Breast
cancer cells possess an extraordinary ability to adapt their energy metabolism,
supporting aggressive growth and metastasis. Dr. Chia-Jung
Li’s latest research dives into the mitochondrial
mechanisms behind this transformation — focusing on the adenine
nucleotide translocase 2 (ANT2) protein and its association
with the ATP
synthasome complex.
The
study provides new evidence showing how functional integration between ANT2 and ATP5B
boosts mitochondrial efficiency, powering the metastatic potential of breast
cancer cells.
🌟 Key Research
Highlights
·
ANT2 Overexpression in Aggressive
Tumors:
Elevated ANT2 levels were linked to poor survival outcomes and increased metastatic
activity in breast cancer tissues.
·
Functional Role in Energy
Production:
ANT2 knockdown significantly reduced ATP generation, OXPHOS
activity, and cell invasion, revealing its central role in tumor
metabolism.
·
Therapeutic Discovery – Cymarin:
Through pharmacogenomic screening, cymarin emerged as a potent ANT2
inhibitor, effectively reducing tumor growth and metastasis in
preclinical models.
·
Mitochondrial Network Insights:
ANT2 was found to interact with ATP5B, forming a powerful ATP
synthasome that enhances energy flux in invasive cancer cells.
·
Clinical Implications:
Targeting ANT2 could be a breakthrough strategy to disrupt
mitochondrial energy flow, limiting cancer progression and
improving patient outcomes.
👨🔬 About the Researcher
Dr.
Chia-Jung
Li is a distinguished mitochondrial biologist and cancer
researcher from Taiwan, renowned for his work on mitochondrial
dysfunction, cellular metabolism, and aging-related diseases.
With over 130
SCI-indexed publications, his research bridges fundamental
biochemistry with translational oncology — driving new directions in mitochondria-targeted
therapies.
🌐 Conference
Information
📍 Event:
International
Conference on Cancer Science and Research
📅 Dates:
November 17–19, 2025
🏛️ Venue:
Singapore & Online (Hybrid)
🔗 Event Website
📧 Email:
cancer@mathewsconference.com
📞 Phone:
+1 (312) 462-4448
💬 WhatsApp:
+1 (424) 377 0967
🐦 X (Twitter):
@CancerWorldConf
📝 Submit
Abstract | Register Now
#ANT2 #BreastCancerResearch
#MitochondrialFunction #CancerMetabolism #ATP #OXPHOS #CancerTherapy
#Mitochondria #Cymarin #Metastasis #OncologyConference #CancerScience2025
#SingaporeConference #CancerResearchInnovation